Endocrine Abstracts

In 24 years old woman in March 2007 was diagnosed acromegaly (somatoprolactinoma) an active phase, hyperprolactinemia. Manifestations: rugged features, amenorrhea, galactorrhea, fasting GH – 144 ng/ml (N<10 ng/ml), IGF-1 – 586 ng/ml (N 48–450 ng/ml), PRL – 6726 mU/l (N 40–530 mU/l). According to pituitary MRT a tumor volume was 14.4 cm3, with supra- and infrasella growth. She was operated in May 2007: transnal transs...

Background: Dulaglutide has been approved as a hypoglycemic agent for the treatment of patients with T2DM. A positive effect on carbohydrate metabolism and body weight was shown in RCT.It was found that GLP-1 agonists may prevent the progression of NAFLD directly affecting lipid metabolism and inflammation.Aim: To assess the effect of dulaglutide on carbohydrate and hepatic metabolism in patients with T2DM and NAFLD in real clinica...

The aim of the study is to compare efficacy of RAI in patients with Graves disease using different methods calculation of optimum therapeutic activity.Methods: About 60 patients (50 women, 10 men, mean age 44.8±11.8 years) with Graves decease were treated with RAI. The treatment with ATD was cancel 10 days before RAI to restore the iodine intake by thyroid gland. Therapeutic activity was determent individually 1) with applied the special formula in ...

Aim: To assess the accuracy of the TBSRTC in verification of thyroid carcinoma in the region of Moscow county.Material and methods: A retrospective study of data from electronic medical notes of 1,675 patients who underwent fine needle aspiration biopsy of nodular thyroid glands in 2016. The cytological conclusion was evaluated in accordance with the TBSRTC. In cases of surgical treatment (thyroidectomy or hemithyroidectomy) the cytological diagnosis was...

Aim: To evaluate the effectiveness of the Bethesda system for reporting thyroid cytopathology in the prediction of thyroid cancer on fine needle aspiration (FNA).Materials and methods: This is retrospective study of 70 detected thyroid cancer. Thyroid ultrasound and FNA were performed on all patients. 66 of them with cancer suspicion were communicated to the thyroid surgeon, 4 cases of papillary carcinoma were accidentally diagnosed after hystological in...

Objective: To evaluate the frequency of symptoms of Cushing’s disease (CD) at baseline and it dependence on different quantities.Material and methods: Clinical and laboratory data of 44 patients with CD (40 females and four males, 37.9±10.5 years old), duration of the disease 35.5 (22; 75) months.Results: Complaints: i) >80% – fatigability, weight gain, apathy, and headache, ii) 40–50% – loss of libido,...

Aim: To estimate the frequency of changes in thyroid function on the background of antiviral therapy in patients with chronic hepatitis C.Material and methods: The retrospective group was consists of 204 patients (mean age 35.5±8.4 years) with HCV genotype 3a, who took the antiviral therapy course with pegylated interferon and ribavirin during 24 weeks. The patients were divided for two groups: 86.3% (176) had a sustained virological response (SVR),...

Background: Excessive level of cortisol in patients with Cushing’s disease (CD) can cause an immunosuppression. Therefore after resolution of hypercorticism the underline autoimmune disorders can appears.Aim: We are presenting three cases of autoimmune disorders diagnosed in patients successfully treated for CD.Results: Case 1: Woman, 37-year-old with confirmed panhypopituitarism after transsphenoidal adenomectomy (TSA) for CD...

Methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. Patients were divided into two groups depending on a type of radical treatment: 76 patients have received radioiodine therapy, 81 persons received surgical treatment. Quality of life assessment was made by SF-36 questionnaire which includes eight scales: (physical functioning (PF), role physical functioning (RPF), pain (B), general ...

Materials and methods: 157 patients (118 women and 39 men) aged from 30 to 73 years with radical treatment for Graves’ disease were included in this study. The patients were divided into two groups depending: (76) included patients with low-normal level of TSH (0.4–2.0 mU/ml), the second group (81 patients) with upper-normal level of TSH 2.1–4.0 mU/ml. Quality of life was assessed with the help of the questionnaire Short-Form SF-36.Results...